HCG Therapy to Increase Male Testes' Natural Testosterone

Human Chorionic Gonadotropin (HCG) is for use in cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males. HCG therapy uses the body's own biochemical stimulating mechanisms to increase plasma testosterone level during HCG therapy. It is used to stimulate the testes of men who are hypogonadal or lack sufficient testosterone.

The male endocrine system is responsible for causing the testes to produce testosterone. The HPTA (hypothalamic-pituitary-testicular axis) regulates the level of testosterone in the bloodstream. and . The hypothalamus produces gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release Leutenizing hormone (LH).

LH released by the pituitary gland then travels from the pituitary via the blood stream to the testes where it triggers the production and release of testosterone. Without the continuing release of LH by the pituitary gland, the testes would shut down their production of testosterone, causing testicular atrophy and stopping natural testosterone produced by the testes.

As men age the volume of hypothalamus produced gonadotropin-releasing hormone (GnRH) declines and causes the pituitary gland to release less Leutenizing hormone (LH). The reduction if the volume of LH released by the Pituitary gland decreases the available LH in the blood stream to stimulate the testes to produce testosterone.

In males, HCG mimics LH and increases testosterone production in the testes. As such, HCG is administered to patients to increase endogenous (natural) testosterone production. The HCG medication administered combines with the patient's own naturally available LH released into the blood stream by the Pituitary gland and thereby increases the stimulation of the testes to produce more testosterone than that produced by the Pituitary released LH alone. The additional HCG added to the blood stream combined with the Pituitary gland's naturally produced LH triggers a greater volume of testosterone production by the testes, since HCG mimics LH and adds to the total stimulation of the testes.

HCG is also administered to men to promote an increase in sperm production or spermatogenesis by the testes. HCG combined FSH or both LH and FSH is also used to increase male spermatogenesis and medially treat male infertility. (Source: Wikipedia)

Clinical Pharmacology - HCG:

The action of HCG is virtually identical to that of pituitary LH, although HCG appears to have a small degree of FSH activity as well. It stimulates production of gonadal steroid hormones by stimulating the interstitial cells (Leydig cells) of the testis to produce androgens.HCG is compounded or manufactured in 5,000 to 20,000 IU (International Units) per 10 cc vials.

HCG is a natural protein hormone secreted by the human placenta and purified form the urine of pregnant women. This hormone is not a natural male hormone but mimics the natural hormone LH (Leutenizing Hormone) almost identically. This LH stimulates the production of testosterone by the testis in males.

Thus HCG sends the same message and results in increased testosterone production by the testis due to HCG's effect on the leydig cells of the testis. HCG therapy uses the bodys own biochemical stimulating mechanisms to increase plasma testosterone level.

When administered, HCG raises serum testosterone very quickly. A rise in testosterone first appears in about two hours after injecting HCG. The second peak occurs about two to four days later.

HCG is not a steroid and is administered to assists the body in the continuing production of its own natural testosterone as a result of LH signals stimulating production of testosterone by the testis.

This LH stimulates the production of testosterone by the testis in males. Thus HCG sends the same message as LH to the testes and results in increased testosterone production by the testes due to HCG's effect on the leydig cells of the testes.

In males, hCG mimics LH and helps restore and maintain testosterone production in the testes. If hCG is used for too long and in too high a dose, the resulting rise in natural testosterone will eventually inhibit its own production via negative feedback on the hypothalamus and pituitary.

HCG therapy uses the body's own biochemical stimulating mechanisms to increase plasma testosterone level during HCG therapy. It is used to stimulate the testes of men who are hypogonadal or lack sufficient testosterone.