Cell-based therapy for erectile dysfunction
July 10, 2008 – 5:50 pmErectile dysfunction (ED) is defined as the pervasive inability to achieve or maintain an erection of sufficient quality for sexual intercourse.1 Erections require the synchronized upsurge in penile artery inflow, dilation of corporal smooth muscle and occlusion of venous outflow. Any factor that compromises these structural changes may lead to ED. Vascular disease is a major cause of ED, and several cardiovascular risk factors such as smoking, aging, hyperlipidemia, diabetes and hypertension are strongly correlated to ED. Injury to the cavernous nerves during pelvic surgeries (for example, radical prostatectomy, radical cystoprostatectomy) comprises an appreciable number of ED cases as well. Other documented causes of ED are side effects of various medications, direct trauma to the genitals, endocrine disorders, and fibrosis of the penile vasculature and corporal smooth muscle.
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